| 2021-06-21 19:30:51June 21, 2021 | Arniston Rangers | 2 - 2 | Vale of Leithen | Friendly | 2021/22 | Newbyres Park | Recap |
| 2021-06-26 14:00:32June 26, 2021 | Vale of Leithen | 2 - 1 | Hawick Royal Albert | Friendly | 2021/22 | Victoria Park | Recap |
| 2021-06-29 19:30:16June 29, 2021 | Vale of Leithen | 4 - 2 | Peebles Rovers | Friendly | 2021/22 | Victoria Park | Recap |
| 2021-07-03 14:00:01July 3, 2021 | Vale of Leithen | 0 - 4 | Cumbernauld Utd | Friendly | 2021/22 | Victoria Park | Recap |
| 2021-07-06 19:30:43July 6, 2021 | Edinburgh South | 1 - 1 | Vale of Leithen | Friendly | 2021/22 | Inch Park | Recap |
| 2021-07-10 14:30:23July 10, 2021 | Craigroyston | 3 - 0 | Vale of Leithen | Friendly | 2021/22 | | Recap |
| 2021-07-17 15:00:57July 17, 2021 | Vale of Leithen | 0 - 4 | Cumbernauld Colts | Lowland League | 2021/22 | Victoria Park | Recap |
| 2021-07-21 19:45:05July 21, 2021 | East Stirlingshire | 1 - 0 | Vale of Leithen | Lowland League | 2021/22 | Falkirk Stadium | Recap |
| 2021-07-24 15:00:34July 24, 2021 | Broomhill | 3 - 0 | Vale of Leithen | Lowland League | 2021/22 | Indodrill Park (Alloa) | Recap |
| 2021-07-28 19:45:07July 28, 2021 | Vale of Leithen | 0 - 2 | Gretna 2008 | Lowland League | 2021/22 | Victoria Park | Recap |
| 2021-07-31 15:00:01July 31, 2021 | Vale of Leithen | 0 - 7 | Bo’ness United | Lowland League | 2021/22 | Victoria Park | Recap |
| 2021-08-07 15:00:41August 7, 2021 | Civil Service Strollers | 7 - 1 | Vale of Leithen | Lowland League | 2021/22 | Marine Drive | Recap |
| 2021-08-11 19:30:17August 11, 2021 | Jeanfield Swifts | 4 - 1 | Vale of Leithen | Football Nation EOS Qualifying Cup | 2021/22 | Riverside Stadium | Recap |
| 2021-08-14 15:00:07August 14, 2021 | Vale of Leithen | 0 - 10 | Celtic B | Lowland League | 2021/22 | Victoria Park | Recap |
| 2021-08-18 19:45:44August 18, 2021 | Vale of Leithen | 1 - 7 | East Kilbride | Lowland League | 2021/22 | Victoria Park | Recap |
| 2021-08-21 15:00:16August 21, 2021 | Caledonian Braves | 4 - 0 | Vale of Leithen | Lowland League | 2021/22 | Alliance Park | Recap |
| 2021-08-28 15:00:52August 28, 2021 | Rangers B | 9 - 0 | Vale of Leithen | Lowland League | 2021/22 | C&G Systems Stadium | Recap |
| 2021-08-31 19:45:36August 31, 2021 | Dalbeattie Star | 4 - 0 | Vale of Leithen | Lowland League | 2021/22 | Islecroft Stadium | Recap |
| 2021-09-04 15:00:23September 4, 2021 | Vale of Leithen | 0 - 8 | Gala Fairydean Rovers | Lowland League | 2021/22 | Victoria Park | Recap |
| 2021-09-11 14:30:31September 11, 2021 | Pumpherston FC | 5 - 1 | Vale of Leithen | South Challenge Cup | 2021/22 | Recreation Park (Pumpherston) | Recap |
| 2021-09-18 15:00:09September 18, 2021 | Brechin City | 5 - 0 | Vale of Leithen | William Hill Scottish Cup | 2021/22 | Glebe Park, Brechin | Recap |
| 2021-10-02 15:00:57October 2, 2021 | Vale of Leithen | 3 - 6 | Stirling University | Lowland League | 2021/22 | Victoria Park | Recap |
| 2021-10-06 19:45:20October 6, 2021 | Vale of Leithen | 0 - 13 | Bonnyrigg Rose | Lowland League | 2021/22 | Victoria Park | Recap |
| 2021-10-09 15:00:40October 9, 2021 | Berwick Rangers | 11 - 0 | Vale of Leithen | Lowland League | 2021/22 | Shielfield Park | Recap |
| 2021-10-23 15:00:11October 23, 2021 | Edinburgh University | 3 - 0 | Vale of Leithen | Lowland League | 2021/22 | Peffermill | Recap |
| 2021-10-30 15:00:28October 30, 2021 | Gretna 2008 | 15:00:2815:00 | Vale of Leithen | Lowland League | 2021/22 | Raydale | Preview |
| 2021-11-06 15:00:43November 6, 2021 | Vale of Leithen | 15:00:4315:00 | East Stirlingshire | Lowland League | 2021/22 | Victoria Park | Preview |
| 2021-11-09 19:45:25November 9, 2021 | Bonnyrigg Rose | 19:45:2519:45 | Vale of Leithen | Lowland League | 2021/22 | New Dundas Park | Preview |
| 2021-11-13 15:00:05November 13, 2021 | Vale of Leithen | 15:00:0515:00 | Spartans | Lowland League | 2021/22 | Victoria Park | Preview |
| 2021-12-04 15:00:43December 4, 2021 | Stirling University | 15:00:4315:00 | Vale of Leithen | Lowland League | 2021/22 | Forthbank | Preview |
| 2021-12-11 15:00:27December 11, 2021 | Bo’ness United | 15:00:2715:00 | Vale of Leithen | Lowland League | 2021/22 | Newtown Park | Preview |
| 2021-12-18 15:00:01December 18, 2021 | Vale of Leithen | 15:00:0115:00 | Civil Service Strollers | Lowland League | 2021/22 | Victoria Park | Preview |
| 2021-12-28 15:00:30December 28, 2021 | Vale of Leithen | 15:00:3015:00 | Rangers B | Lowland League | 2021/22 | Victoria Park | Preview |
| 2022-01-01 15:00:26January 1, 2022 | Gala Fairydean Rovers | 15:00:2615:00 | Vale of Leithen | Lowland League | 2021/22 | Netherdale | Preview |
| 2022-01-08 15:00:15January 8, 2022 | Vale of Leithen | 15:00:1515:00 | Berwick Rangers | Lowland League | 2021/22 | Victoria Park | Preview |
| 2022-01-15 15:00:58January 15, 2022 | Spartans | 15:00:5815:00 | Vale of Leithen | Lowland League | 2021/22 | Ainslie Park | Preview |
| 2022-01-29 15:00:33January 29, 2022 | East Kilbride | 15:00:3315:00 | Vale of Leithen | Lowland League | 2021/22 | K Park | Preview |
| 2022-02-12 15:00:13February 12, 2022 | Celtic B | 15:00:1315:00 | Vale of Leithen | Lowland League | 2021/22 | Excelsior Stadium | Preview |
| 2022-02-19 15:00:46February 19, 2022 | Vale of Leithen | 15:00:4615:00 | Caledonian Braves | Lowland League | 2021/22 | Victoria Park | Preview |
| 2022-02-26 15:00:40February 26, 2022 | Vale of Leithen | 15:00:4015:00 | Dalbeattie Star | Lowland League | 2021/22 | Victoria Park | Preview |
| 2022-04-02 15:00:38April 2, 2022 | Vale of Leithen | 15:00:3815:00 | Broomhill | Lowland League | 2021/22 | Victoria Park | Preview |
| 2022-04-09 15:00:07April 9, 2022 | Cumbernauld Colts | 15:00:0715:00 | Vale of Leithen | Lowland League | 2021/22 | Broadwood | Preview |
| 2022-04-16 15:00:37April 16, 2022 | Vale of Leithen | 15:00:3715:00 | Edinburgh University | Lowland League | 2021/22 | Victoria Park | Preview |
